Magnesium Deficiency and Stress

Magnesium Deficiency and Stress

Magnesium and stress are closely intertwined. During periods of stress, catecholamines and corticosteroids are released; prolonged release of these stress-associated hormones then causes a progressive loss of magnesium from body stores.[i].  Low magnesium levels make people more susceptible to stress, increasing the release of these stress hormones. Low magnesium levels can make the effects of stress more severe, which in turn will reduce magnesium levels, making people even more susceptible to stress, i.e., a vicious circle.[ii]  Researchers have also shown that magnesium deficiency and stress symptoms are very similar, the most common being fatigue, irritability, and mild anxiety.^{[iii] [iv] [v]}

Magnesium Bisglycinate to the Rescue

Magnesium Bisglycinate is a perfect example of getting two great ingredients in one supplement. While we already know that magnesium plays an essential role in stress, glycine (from bisglycinate) has also been shown to have a positive impact. Glycine is an amino acid that functions as an inhibitory neurotransmitter, and decreased amounts of glycine have been linked to anxious behaviors.[vi]  Magnesium Bisglycinate provides consumers with a “two for one” approach to stress and underlying deficiencies linked to stress (magnesium and glycine deficiency.)

Formulating for Stress

When considering formulating a successful formulation for stress, Magnesium Bisglycinate offers a dual approach for your formulating needs.  Not only are you supporting a common nutritional deficiency (magnesium), you are also providing “two ingredients in one” with magnesium and glycine both providing nervous system support.

Gadot manufactures Pure Magnesium Bisglycinate Chelate, also known as Magnesium Glycinate, Magnesium DiGlycinate, Magnesium 2-aminoacetate and Magnesium chelate. Gadot Pure Magnesium Bisglycinate has 10% of magnesium sourced from Marine Origin: the Dead Sea in Israel. Magnesium Bisglicinate is fully reacted, 100% chelated, is Halal Certified, Kosher Certified, and Non-GMO Project Verified. Pure Magnesium Bisglycinate CAS Number: 14783-68-7.

Among the benefits of Gadot Pure Magnesium Bisglycinate: 

• Excellent Solubility
• Neutral Flavor Profile, less metallic taste
• Better Flow Ability
• High Absorption or bioavailability
• No Laxative Effect

The RDA (Recommended Daily Allowance) for Magnesium Bisglycinate for female is 320 mg of magnesium and 420mg for male. 

Main applications: dietary supplements, food supplements, nutraceuticals, sports nutrition, and beverages.

[i] Galland, L. (1991-1992). Magnesium, stress, and neuropsychiatric disorders. Magnesium and Trace Elements, 10(2–4), 287–301.

[ii] Pickering G, Mazur A, Trousselard M, Bienkowski P, Yaltsewa N, Amessou M, Noah L, Pouteau E. Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients. 2020 Nov 28;12(12):3672. doi: 10.3390/nu12123672. PMID: 33260549; PMCID: PMC7761127.

[iii] DiNicolantonio J.J., O’Keefe J.H., Wilson W. Subclinical magnesium deficiency: A principal driver of cardiovascular disease and a public health crisis. Open Heart. 2018;5:e000668. doi: 10.1136/openhrt-2017-000668.

[iv] American Psychological Association Stress Effects on the Body. [(accessed on 30 June 2020)]; Available online: https://www.apa.org/helpcenter/stress

[v]  American Psychological Association Understanding Chronic Stress. [(accessed on 30 June 2020)]; Available online: https://www.apa.org/helpcenter/understanding-chronic-stress.aspx

[vi] Sandra E. File, Peter F. Curle, Helen A. Baldwin, Michael J. Neal, Anxiety in the rat is associated with decreased release of 5-HT and glycine from the hippocampus, Neuroscience Letters, Volume 83, Issue 3,1987, Pages 318-322, ISSN 0304-3940, https://doi.org/10.1016/0304-3940(87)90107-8.